Innovations

Innovative Diagnostic Technologies

Custom Assay Develoment

Cenetron has an active research and development program that is focused on the custom development of assays for pharmaceutical clients. We have developed and validated real-time assay for clinically relevant SNPs used in randomizing patients in Hepatitis C clinical trials. Development of DNA sequencing-based assays for viral resistance testing and specialized immunoassays is also offered at Cenetron. We recently constructed a new research and development laboratory at Cenetron, specially designed for the development of custom molecular tests.

Armored Rna®

Cenetron Diagnostics is the primary inventor of Armored RNA®, which provides custom, stable, quantitative RNA controls for diagnostic assays. This groundbreaking technology provides degradation-resistant quality controls and standards for molecular diagnostic testing.

Armored RNA® stabilizes custom RNA sequences in protective utilizes bacteriophage coat protein. Custom RNA targets form non-infectious, pseudo-viral particles to create ideal standards and controls for RNA viral assays. Armored RNA® is specifically for use as positive controls or quantitative internal spiked controls for amplification and detection using RT-PCR.

Patents

DuBois, D.B., Murray, T.W. Container with view windows. United States Patent and Trademark Office No. D568733 April 26, 2007.

DuBois, D.B., Murray, T.W. Viewable specimen packaging system and method. United States Patent and Trademark Office No. 7341153 March 11, 2008.

B.L. Pasloske, D. DuBois, D. Brown, M. Winkler. Ribonuclease resistant RNA preparation and utilization. United States Patent and Trademark Office. No. 7033749 April 25, 2006.

B.L. Pasloske, D. DuBois, D. Brown, M. Winkler. Methods of quantifying viral load in an animal with a ribonuclease resistant RNA preparation. United States Patent and Trademark Office. No. 6399307 June 4, 2002.

WalkerPeach, C.R., D.B. DuBois. Method for monitoring nucleic acid assays using synthetic internal controls with reversed nucleotide sequences. United States Patent and Trademark Office No. 6395470 May 28, 2002.

B.L. Pasloske, D. DuBois, D. Brown, M. Winkler. Ribonuclease Resistant RNA Preparation and Utilization United States Patent and Trademark Office. No. 5939262 August 17, 1999.

B.L. Pasloske, D.B. DuBois, M. Winkler. Method for large scale RNA synthesis and purification. United States Patent and Trademark Office. No. 5919625 July 6, 1999.

DuBois, D.B., M. Winkler, B.L. Pasloske. Ribonuclease resistant viral RNA standards. United States Patent and Trademark Office No. 5677124 October 14, 1997.